Southampton forward Che Adams was among the scorers as Ralph Hasenhuttl's side won 3-2 at the Tottenham Hotspur Stadium last season.
TEAM NEWS
Tottenham's Oliver Skipp is out with a hairline fracture in his heel, while Yves Bissouma has a minor hamstring strain and will be assessed.
New signing Richarlison serves the final match of a two-game ban after throwing a flare into the stand during Everton's win over Chelsea last season.
Southampton wingers Nathan Tella and Theo Walcott are both sidelined with respective knee and fitness issues.
Full-back Tino Livramento is the only long-term absentee.
Manager Ralph Hasenhuttl is expected to hand debuts to a number of players, including goalkeeper Gavin Bazunu and attacking midfielder Joe Aribo.
MATCH FACTS
Head-to-head
- This is the fourth time Tottenham have begun a league campaign against Southampton, with Spurs winning two and drawing the other.
- The Saints have found the net in each of the last 15 games against Spurs in all competitions.
- Southampton were 3-2 winners in this fixture last season and are seeking successive away league victories at Tottenham for the first time since 1971.
Tottenham Hotspur
- Spurs have won their opening league match in four of the past five seasons (L1).
- Tottenham will play a Premier League home game at 3pm on a Saturday for the first time in 973 days since they beat Burnley 5-0 in December 2019. It's also the first time they've kicked off a league campaign at this time since a goalless draw with Aston Villa in 2001.
- Harry Kane has failed to score in seven of his eight opening-day appearances in the Premier League, the exception being a brace versus Aston Villa in 2019-20.
- However, Kane has 11 goals in 14 games against Southampton.
Southampton
- Southampton have started their Premier League campaign with a defeat in all three seasons under Ralph Hasenhuttl.
- The Saints last won on the opening day nine years ago, a 1-0 victory at West Bromwich Albion in August 2013.
- They've won just once in their past 12 league games (D2, L9) and ended the season with four straight defeats.
- Southampton have won two of their last three league games in London (L1), having mustered just two victories in their 19 previous visits to the capital (D6, L11).
- James Ward-Prowse scored nine of his 10 Premier League goals away from home last season - only Mohamed Salah managed more goals on the road last term with 11.
-- Courtesy of BBC Sport