City beat United 6-3 in October's Manchester derby
City go into the game in second place in the Premier League, four points clear of their old rivals in fourth.
Guardiola has won nine out of 17 meetings with United since replacing Manuel Pellegrini in 2016, losing six.
The Spaniard has finished ahead of the Red Devils in all of his six seasons in charge at City.
-- Courtesy of BBC Sport