Real Madrid head to the Champions League final on the back of one win in four La Liga games
Carlo Ancelotti named his strongest XI for the game between the La Liga champions and the Copa del Rey winners.
Karim Benzema twice went close to scoring but was unable to add to his 27 league goals for the season.
Gareth Bale, who is set to leave Real Madrid, was not involved in the game.
Real Madrid's players gave a guard of honour to Copa del Rey winners Real Betis, before...
...Betis' players returned the compliment by giving La Liga champions Madrid a guard of honour
Ancelotti's team wrapped up the title last month with four games to spare but they were unable to end the domestic campaign on a winning note.
They managed just three attempts on target during the 90 minutes, while Betis went close when 40-year-old substitute Joaquin fired narrowly over on his 600th La Liga appearance.
Real Madrid, who finish the league season on 86 points from 38 games, now have a full week to prepare for the Champions League final in Paris on 28 May.
Real Betis are fifth in the table on 65 points although Real Sociedad can draw level on points if they defeat Atletico Madrid at home on Sunday (21:00 BST).
Ancelotti said on the eve of the game that it was important Real Madrid recognise the contribution Bale made to the club and called on fans to give him a fitting farewell in his final home game.
After naming the Welshman in his squad, the Real boss opted not to include him in his 23.
The 32-year-old, whose contract expires at the end of June, has helped the club win four Champions League trophies and scored 106 goals since joining from Tottenham for £85.3m - then a world transfer record - in September 2013.
Bale has been criticised in Madrid for being perceived to be more committed to playing for Wales than Real.
In March, he hit back at Spanish newspaper Marca for a column which described him as a "parasite".
He has played just seven club games in 2021-22 totalling 290 minutes and scored one goal.
-- Courtesy of BBC Sport